Table II.

Concentration of proteins in the sera of patients with achalasia and controls.

Analyte	Controls, n=39f	Patients, n=68f	Raw P-valuea	Bonferroni adjusted P-valueb
IL-1β	2.49±0.97	1.07±0.52	<0.001e	<0.001e
IL-1Ra	5.16±0.83	4.70±0.76	0.005d	0.127
IL-2	2.77±0.51	1.91±0.49	<0.001e	<0.001e
IL-4	2.78±0.45	2.52±0.41	0.003d	0.082
IL-5	3.67±0.49	3.20±0.48	<0.001e	<0.001e
IL-6	2.72±0.71	1.58±1.09	<0.001e	<0.001e
IL-7	2.98±0.38	2.83±0.40	0.060	1.000
IL-8	5.52±1.39	2.53±0.91	<0.001e	<0.001e
IL-9	5.79±0.18	5.76±0.15	0.259	1.000
IL-10	2.31±0.51	1.64±1.02	<0.001e	0.006d
IL-12p70	1.37±0.93	0.38±0.64	<0.001e	<0.001e
IL-13	2.83±0.78	1.74±0.58	<0.001e	<0.001e
IL-15	5.09±0.58	4.11±0.46	<0.001e	<0.001e
IL-17	3.87±0.51	3.31±0.36	<0.001e	<0.001e
Eotaxin	5.71±0.48	5.68±0.47	0.769	1.000
FGF basic	3.73±0.31	3.52±0.18	<0.001e	<0.001e
G-CSF	7.30±0.68	6.17±0.43	<0.001e	<0.001e
GM-CSF	2.08±0.92	0.06±1.00	<0.001e	<0.001e
IFN-γ	2.75±1.15	0.67±1.14	<0.001e	<0.001e
IP-10	6.32±0.54	6.07±0.54	0.022c	0.602
MCP-1	4.58±0.62	3.94±0.57	<0.001e	<0.001e
MIP-1α	4.16±0.96	2.00±0.76	<0.001e	<0.001e
PDGF-BB	8.46±0.61	8.19±0.47	0.012c	0.323
MIP-1β	5.16±0.33	4.79±0.14	<0.001e	<0.001e
RANTES	9.95±0.50	9.41±0.59	<0.001e	<0.001e
TNF-α	4.10±0.37	3.58±0.27	<0.001e	<0.001e
VEGF	5.57±0.51	4.50±0.64	<0.001e	<0.001e

P-values from a two-sample t-test on log-transformed values for both

^aunadjusted (raw) and

^badjusted for multiple comparisons using a Bonferroni correction.

^cP<0.05,

^dP<0.01,

^eP<0.001.

^flog(pg/ml), mean ± standard deviation. IL, interleukin; FGF basic, fibroblast growth factor basic; G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; IFN, interferon; IP-10, interferon γ-induced protein 10; MCP, monocyte chemoattractant protein 10; MIP, macrophage inflammatory protein; PDGF-BB, platelet-derived growth factor BB; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor.