Table 2.
ESKAPE group insertion sequence families (both Gram-positive and Gram-negative) used by rMAP
|
Sequence name |
Determinant genes |
Conferred resistance |
|---|---|---|
|
IS903 |
aphA1 |
Kanamycin |
|
ISApl1 |
mcr-1 |
Colistin |
|
ISEc69 |
mcr-2 |
Colistin |
|
ISAba14 |
aphA6 |
Kanamycin |
|
ISAba1 |
blaOXA-23 |
Carbapenems, beta-lactams |
|
IS16 |
VanB1 |
Vancomycin |
|
IS256 |
cfr |
Phenicols, lincosamides, oxazolidinones, pleuromutilins, streptogramin A |
|
IS257-2 |
aadD, ble, fosB5, fusB, tetL, tetK, aacA-aphD, vatA, dfrK |
Kanamycin, bleomycin, fosfomycin, fusidic acid, tetracycline, gentamicin, streptogramin A, trimethoprim |
|
IS1182 |
aadE, aphaA-3, sat4 |
Streptomycin, kanamycin, neomycin, streptothricin |
|
IS1216 |
cfr, str |
Phenicols, lincosamides, oxazolidinones, pleuromutilins, streptomycin, streptogramin A |
|
IS1272 |
mecR |
Methicillin |
|
IS1182 |
aphA-3, aadE |
Aminoglycoside |
|
ISEnfa4 |
cfr |
Phenicols, lincosamides, oxazolidinones, pleuromutilins, streptogramin A |
|
ISEcp1 |
CTX-M |
Cefotaxime, ceftriaxone, aztreonam |
|
ISSau1 |
SCCmec |
Methicillin |
|
ISKpn23 |
blaBKC-1 |
Carbapenems, cephalosporins, monobactams |