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. 2021 Sep 13;22(5):1292. doi: 10.3892/etm.2021.10727

Figure 1.

Figure 1

BDNF signaling pathway. BDNF signaling via TrkB and p75NTR is complex. Activation of TrkB-FL by mature BDNF classically leads to activation of PLCγ and both the ERK pathway and the PI3K/Akt pathway promote cell proliferation and survival. In addition, TrkB may act through the NFκB pathway. In contrast to TrkB-FL, the truncated TrkB-T1 may be both inhibitory and activating via RhoA and PKC, resulting in cytoskeletal remodeling, gene modulation and other effects. The low-affinity p75NTR, when activated by mature BDNF, typically activates the pathway including TrkB-FL, but importantly, it may be inhibited via either the JNK or Akt pathways. This is particularly the case when p75NTR is activated by pro-BDNF and forms a ternary complex with the adaptor protein sortilin. BDNF, brain-derived neurotrophic factor; TrkB-FL, tyrosine kinase B full-length; PLC, phospholipase C; PKC, protein kinase C; NTR, neurotrophin receptor; CREB, C-response binding element; RhoA, ras homolog gene family, member A.