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SIN inhibits DSS-induced NLRP3 inflammasome activation. (A) Expression levels of NLRP3 and caspase-1 in colon tissues were analyzed using western blotting. The quantified protein ratios of NLRP3:β-actin and cleaved caspase-1:pro-caspase-1 were analyzed and presented in (B) and (C), respectively. *P<0.05 and **P<0.01 as indicated. DSS, dextran sulfate sodium; NLRP3, NOD-, LRR- and pyrin domain-containing protein 3; SIN, sinomenine hydrochloride.
