Figure 14.
Intrinsic instability of DNA nanostructures under low salt conditions or in the presence of nucleases and fetal bovine serum (FBS) is addressed by many groups. (A) Shih and co-workers could increase the stability of DNA origami by electrostatic coating with PEG–polylysine copolymers.61 Reproduced with permission from ref (61). Copyright 2017 Springer Nature. (B) Block- and brush-type copolymers of PEG and peptide mimetics (so-called peptoids) were found to also reduce the susceptibility of DNA nanostructures.161 Reproduced with permission from ref (161). Copyright 2020 National Academy of Sciences.