Figure 15.

By exploiting the unique addressability of DNA origami, polymer patterning on the nanoscale can be realized. (A) The Gothelf lab developed various strategies to synthesize sophisticated polymers that can be routed on DNA origami platforms on a single-chain level. Furthermore, repetitive switching of the polymer chains was achieved. Switching of the polymer conformation could be monitored by FRET pairs.⁵⁴ Reproduced with permission from ref (54). Copyright 2016 American Chemical Society. (B) The spatially controlled formation of polydopamine in designated patterns was demonstrated by the Weil group by installing enzyme mimicking reaction centers on DNA origami that guided the polymer growth.⁶² Reproduced with permission from ref (62). Copyright 2018 John Wiley and Sons. (C) Further temporal control over polymer formation was implemented by trapping a photosensitizer at distinct positions on 3D origami tubes.⁶⁴ Reproduced with permission from ref (64). Copyright 2020 John Wiley and Sons.