Figure 28.

Construction of a spherical nucleic acid (SNA) system to deliver small molecule drugs. (A) Schematic representation of the self-assembly of the monodisperse BKM120-loaded HE₁₂–SNAs.²¹² Adapted with permission from ref (212). Copyright 2017 the Royal Society of Chemistry. (B) Synthesis of PLGA-SNAs utilizing nanoprecipitation and coumarin encapsulation. Coumarin 6 encapsulated inside the PLGA hydrophobic core was utilized as a fluorescent model drug to evaluate drug-release kinetics.²¹³ Adapted with permission from ref (213). Copyright 2018 John Wiley and Sons.