Figure 29.
Protection of DNA nanostructures from nuclease digestion and denaturation through polymer coating strategies. (A) Cationic polymer was coated on DNA origami to form the polyplex micelles by electrostatic interaction.160 Native DNA nanostructures could be degraded easily by nucleases, but the formed polyplex micelles were resistant to nuclease digestion. Reproduced with permission from ref (160). Copyright 2017 John Wiley and Sons. (B) Schematic representing the differences in stability of native and coated DNA nanostructures in physiological buffers at 37 °C containing low salt and/or 10% FBS.61 Reproduced with permission from ref (61). Copyright 2017 Springer Nature.