Figure 31.
Design and development of various DNA–polymer targeted drugs based on the synergistic functionalities from polymer and DNA. (A) Schematic illustration of DNA–PPO drug delivery system.173 The red targeting units were introduced to the micelles by DNA hybridization, and the green anticancer drug was encapsulated into the core of the micelles. Reproduced with permission from ref (173). Copyright 2008 John Wiley and Sons. (B) DNA aptamer AS1411 was conjugated to HPAEG via the Michael addition reaction and then self-assembled to form the targeting drug delivery carrier.119 Adapted with permission from ref (119). Copyright 2016 American Chemical Society. (C) On-demand and controlled release of a targeted and photoresponsive drug delivery system could be achieved when UV irradiation is applied.120 Reproduced with permission from ref (120). Copyright 2018 John Wiley and Sons. (D) Construction of a hybrid nanoparticle-based drug delivery system. Two different drugs were codelivered into cancer cells with the targeted drug delivery system.221 Reproduced with permission from ref (221). Copyright 2014 the Royal Society of Chemistry.