Figure 5.

DNA–polymer conjugate synthesis summary. Conjugates are categorized as covalently or noncovalently bound. Covalently bound structures can be conjugated either in solution by combining an oligonucleotide with either a linear polymer or a polymer brush.^54,55 Reproduced with permission from ref (54). Copyright 2016 American Chemical Society.⁵⁵ Reproduced with permission from ref (55). Copyright 2015 American Chemical Society. Solid supports, such as beads and DNA nanostructures, can also be adopted to provide a platform for the conjugation.^56,57 Reproduced with permission from ref (56). Copyright 2018 the Royal Society of Chemistry. Reproduced with permission from ref (57). Copyright 2016 John Wiley and Sons. Alternatively, the conjugates can form through noncovalent interactions, such as templating.^58,59 Reproduced with permission from ref (58). Copyright 2011 the Royal Society of Chemistry. Reproduced with permission from ref (59). Copyright 2013 Springer Nature. Nonspecific interactions through complexation in addition to patterning of polymers on DNA are also possible.⁶⁰⁻⁶⁴ Reproduced with permission from ref (60). Copyright 2016 the Royal Society of Chemistry. Reproduced with permission from ref (61). Copyright 2017 Springer Nature. Reproduced with permission from ref (62). Copyright 2018 John Wiley and Sons. Reproduced with permission from ref (63). Copyright 2014 American Chemical Society. Reproduced with permission from ref (64). Copyright 2020 John Wiley and Sons.