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. Author manuscript; available in PMC: 2021 Sep 24.
Published in final edited form as: Peptides. 2020 Aug 27;133:170389. doi: 10.1016/j.peptides.2020.170389

Figure 4. Interaction between leptin and estrogen signaling in neurons.

Figure 4.

Estrogen acting on mER conducts the leptin-independent JAK/STAT signaling, suggesting that the estrogen and leptin signaling are parallel in mediation of anorexigenic action. In contrast, estrogens synergizes leptin signaling, including JAK/STAT and MAPK, through increases expression of leptin receptor ① and conjugation between mER and tyrosine phosphatase Shp2 ②. LepR, leptin receptor; mER, membrane-associated estrogen receptor.