Fig. 1.

The effect of the APOE genotype on decline in cognitive measures before and after transition to AD dementia. Shown are individual data points and locally estimated scatterplot smoothing (LOESS) regression with 70% smoothing and uniform distribution for the following cognitive measures: Mini-Mental State Examination (MMSE) (A), Clinical Dementia Rating Sum of Boxes (CDR-SB) (B), Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-11) (C), and Montreal Cognitive Assessment (MoCA) (D). Negative and positive values on the abscissa depict number of years before and after transition from MCI to AD dementia.