Table 3.
Cox regression models of baseline predictors of PDD
| Model | Variables in model | β | SE | p | HR | HR 95.0% CI | Model fit | AUC 95.0% CI | |||||
| Lower | Upper | LL | χ2 | p | AUC | Lower | Upper | ||||||
| 1SD cut-offs | 292.0 | 60.4 | < 0.001 | 0.835 | 0.761 | 0.910 | |||||||
| MoCA | 1.6 | 0.4 | < 0.001 | 4.9 | 2.3 | 10.4 | |||||||
| SRM No. correct | 0.7 | 0.4 | 0.044 | 2.1 | 1.0 | 4.2 | |||||||
| DV accuracy | 1.0 | 0.4 | 0.008 | 2.7 | 1.3 | 5.6 | |||||||
| PoA | 0.8 | 0.4 | 0.030 | 2.3 | 1.1 | 5.0 | |||||||
| 1.5SD cut-offs | 303.9 | 54.3 | < 0.001 | 0.785 | 0.693 | 0.877 | |||||||
| MoCA | 1.2 | 0.4 | < 0.001 | 3.3 | 1.6 | 6.7 | |||||||
| SRM No. Correct | 1.1 | 0.4 | < 0.001 | 3.1 | 1.5 | 6.1 | |||||||
| PoA | 1.1 | 0.3 | 0.002 | 3.0 | 1.5 | 5.9 | |||||||
| 2SD cut-offs | 305.4 | 59.7 | < 0.001 | 0.758 | 0.658 | 0.858 | |||||||
| MoCA | 1.2 | 0.4 | 0.002 | 3.2 | 1.5 | 6.5 | |||||||
| PRM No. correct | 1.6 | 0.4 | < 0.001 | 5.0 | 2.2 | 11.2 | |||||||
| DV Accuracy | 0.9 | 0.4 | 0.031 | 2.4 | 1.1 | 5.2 | |||||||
| PoA | 1.1 | 0.4 | 0.004 | 3.0 | 1.4 | 6.3 | |||||||
| Pentagons | 2.5 | 1.1 | 0.026 | 12.2 | 1.3 | 111.7 | |||||||
| Median cut-offs | 267.6 | 60.1 | < 0.001 | 0.876 | 0.815 | 0.936 | |||||||
| MoCA | 1.6 | 0.4 | < 0.001 | 4.7 | 2.0 | 11.1 | |||||||
| PAL mean trials to success | 1.2 | 0.5 | 0.008 | 3.4 | 1.4 | 8.4 | |||||||
| DV accuracy | 1.6 | 0.5 | 0.001 | 4.9 | 1.9 | 13.1 | |||||||
| PoA | 1.4 | 0.5 | 0.006 | 3.9 | 1.5 | 10.5 | |||||||
| Median cut-offs: pen and paper | 348.6 | 40.9 | < 0.001 | 0.785 | 0.701 | 0.869 | |||||||
| MoCA | 1.7 | 0.4 | < 0.001 | 5.7 | 2.6 | 12.5 | |||||||
| Semantic fluency | 1.0 | 0.4 | 0.005 | 2.9 | 1.4 | 5.9 | |||||||
| PD-MCI MoCA | 1.7 | 0.4 | < 0.001 | 5.4 | 2.5 | 11.6 | 4.17.8 | 43.3 | < 0.001 | 0.725 | 0.646 | 0.804 | |
| PD-MCI≤1SD to 1.5SD | 1.2 | 0.7 | 0.096 | 3.3 | 0.8 | 13.1 | 71.8 | 3.1 | 0.078 | 0.638 | 0.451 | 0.824 | |
| PD-MCI≤1.5SD to 2SD | 2.3 | 0.8 | 0.002 | 10.3 | 2.3 | 47.0 | 141.1 | 29.6 | < 0.001 | 0.782 | 0.672 | 0.892 | |
| PD-MCI≤2SD | 3.1 | 0.7 | < 0.001 | 21.9 | 5.1 | 94.4 | 173.0 | 44.6 | < 0.001 | 0.814 | 0.720 | 0.907 | |
Significant results after Benjamini–Hochberg procedure are highlighted in bold p < 0.074. Covariates in each model: median age and median MDS-UPDRS part III score. HR, hazard ratio; CI, confidence interval; LL, Log likelihood; AUC, area under the curve; SD, standard deviation; MoCA, Montreal Cognitive Assessment; SRM, spatial recognition memory; PRM, paired recognition memory, DV, Digit Vigilance, PAL, paired associated learning; PoA, power of attention; MDS-UPDRS III, Movement Disorder Society Unified Parkinson’s Disease Rating Scale part III.