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. 2021 Sep 10;12:730346. doi: 10.3389/fimmu.2021.730346

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Copyright © 2021 Johnson-Weaver, Choi, Yang, Granek, Chan, Abraham and Staats

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Small molecule mast cell activators induce mast cell activation after intraperitoneal injection. Five mast cell activating compounds (A) (20 μmoles) or M7-NH2 (200 nmoles) were injected in the peritoneal cavity of naïve BALB/c mice (n= 3-12 mice per group) to monitor for mast cell activation via hypothermia secondary to mast cell degranulation (B). Temperatures were recorded before compound exposure and every 15 minutes after exposure for 45 minutes. Change in body temperature was determined by subtracting pre-exposure temperature from the temperatures recorded 15, 30, and 45 minutes after compound injection. One-way ANOVA determined if compounds induced a significant decrease in core body temperature compared to solvent at a: 15 minutes, b: 30 minutes, and c: 45 minutes after exposure. Bars represent the mean + SD.