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. 2021 Sep 10;12:730346. doi: 10.3389/fimmu.2021.730346

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Copyright © 2021 Johnson-Weaver, Choi, Yang, Granek, Chan, Abraham and Staats

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Small molecule mast cell activators modify gene expression in the NALT after nasal delivery. Lead small molecule mast cell activators, M7 and MPL were nasally administered to C57BL/6 mice (n = 5 mice per group). NALT cells were harvested from each mouse six hours after compound delivery and processed for RNA sequencing. Genes enhanced or inhibited by more than one compound were compared amongst vaccine adjuvants. The Log2 fold-change over vehicle control for each gene is presented.