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. 2021 Sep 13;7(9):1581–1590. doi: 10.1021/acscentsci.1c00811

Figure 1.

Figure 1

In vivo continuous evolution approaches can be far faster than conventional directed evolution methods and require less human intervention, unlocking new chemical potential in enzymes. (a) Overview of small-molecule-dependent PACE for the evolution of selective biocatalysts. (b) Overview of small-molecule-dependent PACS for the selection of selective biocatalysts.