Table 1.

Comparison of stem cell responses in different models of mouse IBD

	DSS	TNBS	Oxazolone	Exacerbated Il10 Deficiency
Putative mechanism of injury	Direct epithelial injury with inflammation	Haptenation of luminal contents	Haptenation of luminal contents	Loss of immunoregulatory signaling
Lgr5+ stem cell persistence	−	+ (most crypts)	+ (most crypts)	+
Ly6a upregulation	+	+	+	+
Secretory cell census	Reduced goblet cells, increased tuft cells	Not grossly affected, perhaps small decrease in goblet cells	Reduced goblet cells	Reduced secretory cell density due to hyperplasia of crypts/expansion of progenitor cell zone
Effect on Lgr5+ stem cells and overall cell survival in organoids	Dose-dependent depletion	Depletion at higher concentrations	Depletion at higher concentrations	Il10−/− Tnfr1−/− organoids did not survive
Functional reliance on Lgr5+ cells	Not tested but previously found to be not reliant (17)	Minor reliance	Not tested	Major reliance