Table 3.
68 upregulated and 18 downregulated genes in JHC7-CMTM3 cells vs. JHC7-MOCK cells (padj < 0.001)
| Gene ID | Gene name | Gene description | Log2 fold change (CMTM3/MOCK) | padj |
|---|---|---|---|---|
| Upregulated DEGs | ||||
| ENSG00000140931 | CMTM3 | CKLF like MARVEL transmembrane domain containing 3 | 12.25 | 6.90E−105 |
| ENSG00000141510 | TP53 | Tumor protein p53 | 11.14 | 9.02E−105 |
| ENSG00000173110 | HSPA6 | Heat shock protein family A (Hsp70) member 6 | 9.65 | 4.80E−88 |
| ENSG00000106211 | HSPB1 | Heat shock protein family B (small) member 1 | 5.42 | 2.11E−55 |
| ENSG00000204388 | HSPA1B | Heat shock protein family A (Hsp70) member 1B | 6.41 | 1.53E−40 |
| ENSG00000204389 | HSPA1A | Heat shock protein family A (Hsp70) member 1A | 6.93 | 5.06E−39 |
| ENSG00000132002 | DNAJB1 | DnaJ heat shock protein family (Hsp40) member B1 | 4.66 | 6.02E−25 |
| ENSG00000149257 | SERPINH1 | Serpin family H member 1 | 3.61 | 7.00E−24 |
| ENSG00000105550 | FGF21 | Fibroblast growth factor 21 | 4.44 | 2.35E−19 |
| ENSG00000151929 | BAG3 | BCL2 associated athanogene 3 | 3.53 | 6.39E−19 |
| ENSG00000120694 | HSPH1 | Heat shock protein family H (Hsp110) member 1 | 3.50 | 9.56E−16 |
| ENSG00000109846 | CRYAB | Crystallin alpha B | 3.51 | 8.51E−14 |
| ENSG00000130513 | GDF15 | Growth differentiation factor 15 | 2.66 | 5.81E−13 |
| ENSG00000080824 | HSP90AA1 | Heat shock protein 90 alpha family class A member 1 | 3.77 | 1.56E−12 |
| ENSG00000100292 | HMOX1 | Heme oxygenase 1 | 4.62 | 7.00E−12 |
| ENSG00000004478 | FKBP4 | FK506 binding protein 4 | 2.56 | 9.83E−11 |
| ENSG00000109971 | HSPA8 | Heat shock protein family A (Hsp70) member 8 | 2.70 | 7.19E−09 |
| ENSG00000130766 | SESN2 | Sestrin 2 [Source:HGNC Symbol;Acc:HGNC:20746] | 2.24 | 8.27E−09 |
| ENSG00000099875 | MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 2.39 | 3.77E−07 |
| ENSG00000100591 | AHSA1 | Activator of HSP90 ATPase activity 1 | 2.07 | 5.39E−07 |
| ENSG00000188483 | IER5L | Immediate early response 5 like | 2.72 | 6.14E−07 |
| ENSG00000168439 | STIP1 | Stress induced phosphoprotein 1 | 2.35 | 3.19E−06 |
| ENSG00000168209 | DDIT4 | DNA damage inducible transcript 4 | 2.71 | 3.41E−06 |
| ENSG00000174951 | FUT1 | Fucosyltransferase 1 (H blood group) | 2.45 | 3.48E−06 |
| ENSG00000115541 | HSPE1 | Heat shock protein family E (Hsp10) member 1 | 2.14 | 3.58E−06 |
| ENSG00000128965 | CHAC1 | ChaC glutathione specific gamma-glutamylcyclotransferase 1 | 2.56 | 3.90E−06 |
| ENSG00000116161 | CACYBP | Calcyclin binding protein | 2.16 | 4.86E−06 |
| ENSG00000224411 | HSP90AA2P | Heat shock protein 90 alpha family class A member 2, pseudogene | 3.45 | 6.23E−06 |
| ENSG00000178381 | ZFAND2A | Zinc finger AN1-type containing 2A | 1.98 | 8.53E−06 |
| ENSG00000110680 | CALCA | Calcitonin related polypeptide alpha | 8.18 | 8.98E−06 |
| ENSG00000087074 | PPP1R15A | Protein phosphatase 1 regulatory subunit 15A | 2.47 | 9.76E−06 |
| ENSG00000175084 | DES | Desmin | 2.42 | 9.94E−06 |
| ENSG00000086061 | DNAJA1 | DnaJ heat shock protein family (Hsp40) member A1 | 2.01 | 9.94E−06 |
| ENSG00000121068 | TBX2 | T-box 2 | 2.47 | 1.06E−05 |
| ENSG00000162783 | IER5 | Immediate early response 5 | 1.91 | 1.06E−05 |
| ENSG00000121769 | FABP3 | Fatty acid binding protein 3 | 2.16 | 1.06E−05 |
| ENSG00000096384 | HSP90AB1 | Heat shock protein 90 alpha family class B member 1 | 2.18 | 1.43E−05 |
| ENSG00000161180 | CCDC116 | Coiled-coil domain containing 116 | 4.54 | 1.75E−05 |
| ENSG00000258469 | CHMP4BP1 | Charged multivesicular body protein 4B pseudogene 1 | 3.80 | 2.01E−05 |
| ENSG00000028277 | POU2F2 | POU class 2 homeobox 2 | 3.27 | 2.38E−05 |
| ENSG00000110172 | CHORDC1 | Cysteine and histidine rich domain containing 1 | 2.21 | 3.93E−05 |
| ENSG00000008517 | IL32 | Interleukin 32 | 2.40 | 4.39E−05 |
| ENSG00000139269 | INHBE | Inhibin subunit beta E | 3.70 | 4.39E−05 |
| ENSG00000087086 | FTL | Ferritin light chain | 2.01 | 4.95E−05 |
| ENSG00000144381 | HSPD1 | Heat shock protein family D (Hsp60) member 1 | 1.98 | 5.26E−05 |
| ENSG00000225217 | HSPA7 | Heat shock protein family A (Hsp70) member 7 | 7.46 | 5.27E−05 |
| ENSG00000101255 | TRIB3 | Tribbles pseudokinase 3 | 2.20 | 5.27E−05 |
| ENSG00000116717 | GADD45A | Growth arrest and DNA damage inducible alpha | 1.79 | 5.27E−05 |
| ENSG00000149781 | FERMT3 | Fermitin family member 3 | 3.99 | 5.98E−05 |
| ENSG00000183696 | UPP1 | Uridine phosphorylase 1 | 1.80 | 6.76E−05 |
| ENSG00000064300 | NGFR | Nerve growth factor receptor | 3.84 | 1.04E−04 |
| ENSG00000164045 | CDC25A | Cell division cycle 25A | 1.93 | 1.05E−04 |
| ENSG00000200879 | SNORD14E | Small nucleolar RNA, C/D box 14E | 5.05 | 1.10E−04 |
| ENSG00000148926 | ADM | Adrenomedullin | 2.24 | 1.20E−04 |
| ENSG00000167513 | CDT1 | Chromatin licensing and DNA replication factor 1 | 2.02 | 1.20E−04 |
| ENSG00000282855 | AC093591.3 | INTS3 and NABP interacting protein (INIP) pseudogene | 4.03 | 1.43E−04 |
| ENSG00000123358 | NR4A1 | Nuclear receptor subfamily 4 group A member 1 | 2.01 | 1.74E−04 |
| ENSG00000211891 | IGHE | Immunoglobulin heavy constant epsilon | 6.74 | 1.96E−04 |
| ENSG00000131094 | C1QL1 | Complement C1q like 1 | 1.69 | 2.43E−04 |
| ENSG00000105219 | CNTD2 | Cyclin N-terminal domain containing 2 | 2.56 | 3.06E−04 |
| ENSG00000088826 | SMOX | Spermine oxidase | 1.76 | 4.19E−04 |
| ENSG00000068028 | RASSF1 | Ras association domain family member 1 | 1.89 | 4.19E−04 |
| ENSG00000175183 | CSRP2 | Cysteine and glycine rich protein 2 | 2.22 | 5.01E−04 |
| ENSG00000213430 | HSPD1P1 | Heat shock protein family D (Hsp60) member 1 pseudogene 1 | 2.20 | 5.33E−04 |
| ENSG00000237596 | AL138828.1 | Novel transcript | 3.98 | 6.21E−04 |
| ENSG00000127564 | PKMYT1 | Protein kinase, membrane associated tyrosine/threonine 1 | 2.14 | 7.75E−04 |
| ENSG00000066735 | KIF26A | Kinesin family member 26A | 2.13 | 9.19E−04 |
| ENSG00000164070 | HSPA4L | Heat shock protein family A (Hsp70) member 4 like | 1.99 | 9.97E−04 |
| Downregulated DEGs | ||||
| ENSG00000147724 | FAM135B | Family with sequence similarity 135 member B | − 2.91 | 1.04E−07 |
| ENSG00000147041 | SYTL5 | synaptotagmin like 5 | − 2.36 | 3.81E−06 |
| ENSG00000155850 | SLC26A2 | Solute carrier family 26 member 2 | − 2.01 | 5.79E−06 |
| ENSG00000103489 | XYLT1 | Xylosyltransferase 1 | − 1.88 | 1.15E−05 |
| ENSG00000203727 | SAMD5 | Sterile alpha motif domain containing 5 | − 1.97 | 1.61E−05 |
| ENSG00000146938 | NLGN4X | Neuroligin 4 X-linked | − 2.06 | 2.08E−05 |
| ENSG00000176055 | MBLAC2 | Metallo-beta-lactamase domain containing 2 | − 3.08 | 3.93E−05 |
| ENSG00000073282 | TP63 | Tumor protein p63 | − 3.57 | 4.30E−05 |
| ENSG00000232727 | YWHAEP1 | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon pseudogene 1 | − 2.16 | 1.04E−04 |
| ENSG00000114019 | AMOTL2 | Angiomotin like 2 | − 2.01 | 1.20E−04 |
| ENSG00000143971 | ETAA1 | ETAA1, ATR kinase activator | − 2.04 | 2.23E−04 |
| ENSG00000082482 | KCNK2 | Potassium two pore domain channel subfamily K member 2 | − 1.67 | 2.40E−04 |
| ENSG00000225980 | OR7E19P | Olfactory receptor family 7 subfamily E member 19 pseudogene | − 3.05 | 2.43E−04 |
| ENSG00000280798 | LINC00294 | Long intergenic non-protein coding RNA 294 | − 1.78 | 4.11E−04 |
| ENSG00000138380 | CARF | Calcium responsive transcription factor | − 2.40 | 5.01E−04 |
| ENSG00000143669 | LYST | lysosomal trafficking regulator | − 1.56 | 6.21E−04 |
| ENSG00000250305 | TRMT9B | tRNA methyltransferase 9B (putative) | − 2.14 | 7.52E−04 |
| ENSG00000104432 | IL7 | Interleukin 7 | − 1.62 | 8.32E−04 |