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. 2021 Sep 23;21:508. doi: 10.1186/s12935-021-02208-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — ARF4 binds to USP7 and is downregulated by USP7 inhibition

A-C Proteins bound to USP7 were identified in SHG-140 by Co-IP and MS, and the screened proteins were analyzed for the KEGG pathway. D Heat map showing the comparative results of TMT proteomics analysis after 48 h treatment using DMSO or P5091 (2µM) in SHG-140. E Venn diagram showing down-regulated proteins in response to P5091 (yellow), USP7 interaction candidates identified by Co-IP (purple), and overlapping proteins. F Volcano plot showing the differential proteins from TMT proteomics analysis and the location of ARF4