Fig. 6.

P5091 inhibits tumorigenicity in intracranial xenograft models

Female BALB/c nude mice were injected intraperitoneally with PBS, P5091 (5 mg/kg/day, 10 mg/kg/day) and treated 2 days per week. Treatment started on day 7 after implantation and lasted for approximately 21 days. A Representative images of bioluminescence in mice on days 7, 14 and 28 after implantation. B Quantitative analysis of these bioluminescence images, n = 6. C Overall survival of the PBS and P5091 treatment groups, n = 6. D Representative H&E images of tumor sections. Scale bar, 300 μm. E Representative IHC images of tumor sections for anti-USP7, anti-ARF4, anti-BAX, anti-BCL-2, and anti-CLEAVED-CASPASE. Scale bar, 300 μm. Statistics are expressed as mean ± S.E.M., ^#P = NS, *P < 0.05,**P < 0.01 or ****P < 0.0001