Table 1.
Critically ill coronavirus disease-2019 elderly patients, included in observational clinical studies conducted in intensive care units
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Ref.
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Country
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Median age, yr
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Sample size / No. of the elderly admitted to the ICU (proportion, %)
|
ICU mortality, No. of deaths (%), all ages
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ICU mortality of the elderly, No. of deaths and proportion (%)
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Comments
|
| Yang et al[8], Lancet Respir Med | China | 59.71 | 52 / 27 ≥ 60 yr (52) | 32 (61.5) | 20/27 (74.1) (≥ 60 yr) | - |
| Grasselli et al[23], JAMA | Italy | 63 | 1591 / 961 ≥ 61 yr (60.4) | 405 (60.3) | 322/436 (73.9) (≥ 61 yr) | 525/961 elderly patients still in ICU; 920/1591 patients (all ages) still in ICU |
| Richardson et al[24], JAMA | United States | N/A | 1281 / 613 ≥ 65 yr (47.8) | 291 (78) | 182/200 (91) (≥ 65 yr) | 413/613 patients ≥ 65 yr old still in hospital; 908/1281 patients (all ages) still in hospital |
| Bhatraju et al[49], NEJM | United States | 641 | 24 / N/A | 12 (57.1) | 62 (≥ 65 yr) | 3 patients remained intubated at the end of the study |
| Karagiannidis et al[52], Lancet Respir Med | Germany | 71 | 1727 / 1305 ≥ 60 yr (75.5)535, 70-79 yr; 388, ≥ 80 yr | 906 (53) | 174/382 (46), 60-69 yr; 335/535 (63), 70-79 yr; 280/388 (72), ≥ 80 yr | ICU deaths in elderly with invasive and non-invasive mechanical ventilation are reported |
| Yu et al[47], Crit Care | China | 64 | 226 / 149 ≥61 yr (65.9) | 87 (41.2) | 62/140 (44) (≥ 61 yr) | 9/149 elderly patients still in hospital; 15/226 patients (all ages) still in hospital |
| Shi et al[34], Clin Lab Anal | China | 59.41 | 161 / 83 ≥ 60 yr (51.5) | 50 (39) | 36 (60-74 yr)24.24 (> 74 yr) | Further comparison analysis revealed that no difference was found among the following age group patients: ≤ 44, 45-59, 60-74, and ≥ 75 yr; 33/161 still in hospital- N/A if they were in ICU or in hospital’s ward |
| Burrell et al[35], MJA | Australia | 63.5 | 200 / 123 ≥ 60 yr (61.5); 97 ≥ 65 yr (48.5) | 30 (15) | 28/123 (22.8) (≥60 yr); 25/97 (25.8) (≥ 65 yr) | 6/200 patients still in hospital wards |
| Aleva et al[36], J Crit Care | The Netherlands | 651 | 50 / 30 ≥ 65 yr (60) | 13 (32) | 10/30 (33) (≥ 65 yr) | All survivors successfully discharged from the hospital |
| Mitra et al[37], CMAJ | Canada | 69 | 117 / 76 ≥ 65 yr (64.9) | 18 (17.1) | 16/69 (23) (≥ 65 yr) | 7/76 elderly patients still in ICU; 12/69 elderly patients still hospitalized; 12/117 patients (all ages) still in ICU |
| Alshukry et al[38], PLoS One | Kuwait | 47 | 82 / 25 > 60 yr (30.4) | 60 (73.1) | 17/25 (68) (> 60 yr) | - |
| Larsson et al[39], Acta Anesthesiol Scand | Sweden | 59 | 260 / 110 ≥ 60 yr (42.3); 28 ≥ 70 yr (10.7) | 60 (30.3) | 37/81 (45.7) (≥ 60 yr) | 29/110 elderly patients still in ICU; 62/260 patients (all ages) still in ICU |
| Wang et al[42], AJRCCM | China | 60 | 344 / 194 ≥ 60 yr (56.4) | 133 (38.7) | 101/194 (52.1) (≥ 60 yr) | - |
| Auld et al[46], Crit Care Med | United States | 64 | 217 / 106 ≥ 65 yr (48.8) | 62 (29.7) | 45/103 (44) (≥ 65 yr) | 3/106 elderly patients still in ICU; 8/217 patients (all ages) still in ICU |
| Xu et al[48], Crit Care | China | 239 / 112 ≥ 65 yr (46.9) | 147 (61.5) | 82/112 (73.2) (≥ 65 yr) | - | |
| Thomson et al[50], PLoS One | United Kingdom | 62 | 156 / 89 ≥ 60 yr (57) | 38 (24.3) | 31/89 (34.8) (≥ 60 yr) | - |
| Nachtigall et al[51], Clin Microbiol Infect | Germany | 73 | 399 / 318 ≥ 60 yr (79.6) | 109 (27.3) | 102/318 (32) (≥ 60 yr) | - |
| Guillon et al[32], Intensive Care Med | France | N/A | 9885 / 5126 ≥ 65 yr (51.9); 480 ≥ 80 yr (4.9) | 2914 (29.5) | 1986/5126 (38.7) (≥ 65 yr); 300/480 (62.5) (≥ 80 yr) | - |
| Dres et al[33], Ann Intensive Care | France, Switzerland, Belgium | 74 | 1199 / 639 70-74 yr (53.3); 367 75-79 yr (30.6); 193 > 80 yr (16.1) | 549 (45.8) | 247/639 (38.7) (70-74 yr); 173/367 (47.1) (75-79 yr); 129/193 (66.8) (> 80 yr) | All patients were ≥ 70 yr old |
1
mean value. ICU: Intensive care unit; N/A: Not available.