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. Author manuscript; available in PMC: 2021 Sep 24.
Published in final edited form as: Mol Biol (Mosk). 2019 Nov-Dec;53(6):883–898. doi: 10.1134/S0026898419060090

Figure 2. Rare codon clusters are often non-randomly and strategically placed within mRNAs.

Figure 2.

Top – codon usage profile for Bovine (Bos taurus) βB2 crystallin revealing an extended cluster of rare codons partially encoding the domain linker and the adjacent downstream region of the protein structure. Bottom – backbone/cartoon structure of the βB2 crystallin (PDB 2BB2). The N-terminal domain is in blue, the C-terminal domain is in yellow and a portion of the linker connecting the two domains is shown in gray. Positions of Pro80 and Lys89 at the beginning and the end of the linker peptide connecting the domains are indicated; Asn95 marks the end of the first β-structure in the βB2 C-terminal domain.