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. Author manuscript; available in PMC: 2022 Aug 10.
Published in final edited form as: Int J Pharm. 2021 Jul 1;605:120844. doi: 10.1016/j.ijpharm.2021.120844

Figure 6.

Figure 6.

In vivo safety evaluation of PSIs in BALB/c mice (n=7 per timepoint). A) Local inflammation of implanted subcutaneous tissues collected at day 3, 7, 14, 30, and 60 post-implantation and stained with H&E. Arrows indicate areas of inflammation identified by a certified anatomic pathologist. All scale bars represent 1 mm. B) Inflammatory scores of implanted subcutaneous tissues evaluated using light microscope, and blindly scored by a certified pathologist. The bars represent the median of inflammation scores in each group at each timepoint (n=7 per group). C) Concentration of IL-6 (pg/mL) in plasma post-PSI implantation quantified by ELISA (n=4 per group). D) Concentration of TNF-α (pg/mL) in plasma post-PSI implantation quantified by ELISA (n=4 per group).