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. 2021 Sep 10;11:697967. doi: 10.3389/fonc.2021.697967

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Copyright © 2021 Zaryouh, De Pauw, Baysal, Pauwels, Peeters, Vermorken, Lardon and Wouters

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quantification of the human phospho-kinase array blots of cetuximab sensitive (SC263-S and SCC22b-S) HNSCC cell lines and corresponding acquired cetuximab resistant (SC263-R and SCC22b-R) variants. Graph represents the fold change of selected substrates, i.e. phosphorylated EGFR, Akt1/2/3 and other substrates involved in the Akt pathway, after cetuximab treatment. Protein phosphorylation profiling was conducted with one cell lysate. The fold changes were calculated by the ratio of the mean integrated optical density (duplicates) in treatment versus control groups. Error bars were calculated based on differences between duplicates. Suffix -S: cetuximab sensitive cell line and suffix -R: acquired cetuximab resistant cell line.