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. 2021 Sep 10;11:697967. doi: 10.3389/fonc.2021.697967

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Copyright © 2021 Zaryouh, De Pauw, Baysal, Pauwels, Peeters, Vermorken, Lardon and Wouters

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The cytotoxic effect of cetuximab for 168h with MK2206 added during the last 72h of treatment. Dose-response curves for the cetuximab sensitive HNSCC cell lines SC263-S (A) and SCC22b-S (B) show a synergistic interaction. Regarding the acquired cetuximab resistant variants, dose-response curves indicate a synergistic and additive effect in SC263-R (C) and SCC22b-R (D), respectively. Survival curves were corrected for the cytotoxic effect of cetuximab alone. Cells were treated with fixed concentrations of cetuximab, which were based on the outcome of previous monotherapy experiments. Suffix -S: cetuximab sensitive cell line and suffix -R: acquired cetuximab resistant cell line.