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. 2021 Sep 3;12:729705. doi: 10.3389/fimmu.2021.729705

Figure 1.

Figure 1

Roles of infiltrating immune cells in HCC. (A) The suppressing role of TILs on HCC. Initially, several infiltrating T lymphocytes, including CD3+, CD8+, activated NKs and Foxp3+ TILs, have been discovered to inhibit HCC directly. Secondly, some TILs could interact with other immune cells to suppress HCC, such as TIBs prohibited HCC by increasing CD8+ T cells and activating NK cells. Last, different TIL ratios also were proved to hinder HCC progress, just as low Foxp3+/CD3+ TIL ratio, high CD4+/CD8+ TIL ratio, et al. (B) The promoting role of TILs on HCC. Some infiltrating T lymphocytes have been shown to promote HCC directly, like Foxp3+, CD3+ TILs. Also, infiltrating T lymphocytes could interact with other immune cells to boost HCC progress via many mechanisms, including reduced DC-T interaction, weakening the function of CD4+ and CD8+ TILs et al.