Table 2. Total kidney, liver volumes, and estimated glomerular filtration rate reported in (or estimated from) the included studies.
| Study, year | Follow-up | Somatostatin | Control | ||||
|---|---|---|---|---|---|---|---|
| Pre-treatment | Post-treatment | Estimated or Reported Change % (mean ± SD) | Pre-treatment | Post-treatment | Estimated or Reported Change % (mean ± SD) | ||
| Total Liver Volumes (mL) | |||||||
| LOCKCYST, 2009 | 6 months | 4606 (547–8665)‡ | 4471 (542–8401)‡ | -2.9 ± 15.5 | 4689 (613–8765)‡ | 4896 (739–9053)‡ | 1.6 ± 12.8 |
| Caroli, 2010 | 6 months | 1595 ± 478 | 1524 ± 453 | -4.03 ± 3.33 | 1580 ± 487 | 1594 ± 480 | 1.23 ± 6.46 |
| Hogan, 2010 | 1 year | 5907.7 ± 2915.0 | 5557.1 ± 2659.4 | -5.0 ± 6.77 | 5373.9 ± 3565.4 | 5360.6 ± 3330.9 | 0.9 ± 8.33 |
| Pisani, 2016 | 3 years | 1609.7 ± 501.2 | 1479.5 ± 470.9 | -7.8 ± 7.4 | 1693.0 ± 470.7 | 1837.2 ± 748.5 | 6.1 ± 14.1 |
| Van Aerts, 2019 | 6 months | 2781 (2272–4230)* | -1.99 ± 3.30 ¶ | 2389 (2168–3029)* | 3.92 ± 3.50 ¶ | ||
| Hogan, 2020 | 1 year | 2582 ± 1381 | 2479 ± 1317 | -3.4 ± 7.3 | 2387 ± 759 | 2533 ± 770 | 6.3 ± 7.0 |
| Total Kidney Volumes (mL) | |||||||
| Ruggenenti, 2005 | 6 months | 2551 ± 1053 | 2622 ± 1111 | 2.2 ± 3.7 | 2461 ± 959 | 2623 ± 1021 | 5.9 ± 5.4 |
| LOCKCYST, 2009 | 6 months | 1000 (-39-2039)‡ | 983 (-62~2028) ‡ | -1.5 ± 31.1 | 1115 (-519~2748) ‡ | 1165 (-541~2871) ‡ | 3.4 ± 28.0 |
| Hogan, 2010 | 1 year | 1142.9 ± 826.9 | 1128.5 ± 796 | 0.25 ± 7.53 | 803 ± 269.1 | 873.5 ± 306.2 | 8.61 ± 10.07 |
| ALADIN, 2013 | 1 year | 1556.9 ± 1035.1† | 1603.1 ± 176.1† | 2.97 ± 7.41 | 2161.2 ± 1274.9† | 2304.9 ± 224.6† | 6.65 ± 5.31 |
| 3 years | 1556.9 ± 1035.1† | 1672.7 ± 202.0† | 14.14 ± 19.95 | 2161.2 ± 1274.9† | 2621.0 ± 271.0† | 21.02 ± 32.41 | |
| DIPAK 1, 2018 | 1 year | 2046 (1383–2964)* | N/A | 4.15 ± 5.20 | 1874 (1245–2868)* | N/A | 5.56 ± 5.06 |
| ALADIN 2, 2019 | 1 year | 2338.9 (1967.6–3807.4)* | 2513.3 (2023.6–3923.5)* | 5.2 ± 6.37 | 2591.0 (1959.3–3855.7)* | 2935.1 (2197.1–4094.4)* | 8.8 ± 6.15 |
| 3 years | |||||||
| 2338.9 (1967.6–3807.4)* | 3043.9 (2337.3–5470.6)* | 29.9 ± 21.33 | 2591.0 (1959.3–3855.7)* | 3613.8 (2584.1–4866.8)* | 37.1 ± 23.26 | ||
| Hogan, 2020 | 1 year | 534 ± 343 | 523 ± 325 | -1.4 ± 3.5 | 397 ± 159 | 417 ± 177 | 3.9 ± 4.5 |
| Estimated Glomerular Filtration Rate (mL/min./1.73m 2 ) | |||||||
| Ruggenenti, 2005 | 6 months | 59.5 ± 25.2 | 54.0 ± 23.6 | -5.5 ±10.75 | 57.9 ± 22.49 | 57.7 ± 25.7 | -0.2 ± 7.33 |
| Hogan, 2010 | 1 year | 68.1 ± 26.53 | 64.6 ± 25.66 | -5.1 ± 15.46 | 70.8 ± 28.08 | 65.7 ± 26.40 | -7.2 ± 13.21 |
| ALADIN, 2013 | 1 year | 88.68 ± 3.93† | 77.86 ± 4.23† | -10.82 ± 7.03 | 77.77 ± 5.30† | 72.16 ± 5.45† | -5.61 ± 4.09 |
| 3 years | 88.68 ± 3.93† | 76.33 ± 4.66† | -3.85 ± 3.17 | 77.77 ± 5.30† | 64.64 ± 6.51† | -4.95 ± 4.13 | |
| DIPAK 1, 2018 | 1 year | 51.0 ± 11.5 | -3.53 ± 2.93 | 51.4 ± 11.2 | -3.46 ± 1.39 | ||
| ALADIN 2, 2019 | 1 year | 27.9 (23.5–32.1)* | 22.5 (17.3~27.7)* | -6.2 ± 2.5 | 25.8 (19.5~33.2)* | 20.2 (14.7~28.1)* | -6.5 ± 0.8 |
| 3 years | 27.9 (23.5–32.1)* | 14.9 (11.3~20.2)* | -4.26 ± 2.00 | 25.8 (19.5~33.2)* | 15.0 (7.5~24.4)* | -4.19 ± 2.52 | |
| Hogan, 2020 | 1 year | 74 ± 24 | 73 ± 22 | -0.3 ± 14 | 74 ± 18 | 73 ± 22 | -2.2 ± 17.7 |
Mean±SD.
*Median (IQR).
† mean ± SE.
‡ 95%CI.
¶ hight adjusted TLV