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. 2020 Sep 14;26(7):3292–3301. doi: 10.1038/s41380-020-00878-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Relationship between post-ketamine, compared with post-placebo, increases in fronto-striatal functional connectivity and improvements (negative numbers indicate post-ketamine improvements compared with post-placebo) in anhedonia symptoms on the day of the resting-state functional magnetic resonance imaging (rsfMRI) scan (2 days post infusion; a), and 10 days post infusion (b–d) in individuals with treatment-resistant depression (TRD). Shaded area represents estimated 95% confidence interval. SHAPS Snaith–Hamilton Pleasure Scale; DC dorsal caudate; vlPFC ventrolateral prefrontal cortex; DCP dorsal caudal putamen; pgACC perigenual anterior cingulate cortex; VRP ventral rostral putamen; OFC orbitofrontal cortex; Δ ketamine minus placebo.