Table 2. Markers used to identify various cell types in the lung.
Cell type | Markers |
---|---|
AT1 | AQP5*$, PDPN*$$, Carboxypeptidase M, CAV-1, CAV-2, HTI56, HOPX, P2R × 4*$$, Na+/K + ATPase$, TIMP3*++, SEMA3F PDPN* AQP5* P2R × 4* TIMP3* SERPINE* |
AT2 | ABCA3*$$, CC10 (SCGB1A1*)+, CD44v6, Cx32, gp600++, ICAM-1++, KL-6, LAMP3*$$, MUC1, SFTPA1*$$, SFTPB*$, SFTPC*+, SFTPD*, SERPINE1 |
Club | CC10 (SCGB1A1*)+, CYP2F2*, ITAG6*$$, SCGB3A2*$$, SFTPA1*$$, SFTPB*$, SFTPD* |
Goblet | CDX-2*, MUC5AC*, MUC5B*, TFF3*, UEA1+ |
Ciliated | ACT (ACTG2*)$, BTub4 (TUBB4A*), FOXA3*++, FOXJ1*, SNTN* |
Basal | CD44v6 (CD44*), ITGA6*$$, KRT5*$, KRT13*, KRT14*, p63 (CKAP4*), p75 (NGFR*)$$ |
Generic Lung Lineage | Cx43 (GJA1*), TTF-1 (TTF1*; Greatest in AT2 & Club), EpCAM (EPCAM*) |
*Markers used for single-cell gating (Figure 1A).
$ denotes markers used in this work for Immunofluorescence (IF).
$$ denotes markers used in this work for qPCR.
+ denotes markers used in both IF and qPCR.
++ denotes obscure markers (Not a lot of research relative to lung).