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. 2021 Aug 13;10:e66417. doi: 10.7554/eLife.66417

Table 4. Upregulated genes and pathways: healthy vs COVID-19 lung (GSE151764).

Genes
BRCA2 XAGE1B CDK1 SNAI2 CXCL11
CYBB CCR5 GBP1 IFITM1 IFI27
KRT5 CCR2 HLA-G GZMB IFI35
C1QB ALOX15B IDO1 CD163 TDO2
FCGR1A CMKLR1 ISG20 CD38 GZMA
IL10 MX1 LAG3 BST2 OAS3
IL6 TNFRSF17 MAD2L1 BUB1 POU2AF1
CD44 CCR1 CXCL9 CCL20 CXCL13
CD276 CXCR3 MKI67 CCNB2 GNLY
DMBT1 SLAMF8 IFIT2 TNFSF18 IFIT3
DDX58 IL21 IFIT1 ISG15 TOP2A
TNFAIP8 FOXM1 CXCL10 CDKN3 LILRB1
LAMP3 IFIH1 IRF4 C1QA HERC6
KIAA0101 IFI6 PSMB9 OAS1 TNFSF13B
MELK PDCD1LG2 CCL18 OAS2 IFI44L
Pathways STAT1
Name p-value FDR
Interferon signaling 1.11E-16 1.11E-14
Interferon alpha/beta signaling 1.11E-16 1.11E-14
Cytokine signaling in immune system 1.11E-16 1.11E-14
Immune ssystem 1.11E-16 1.11E-14
Interleukin-10 signaling 9.85E-13 7.88E-11
Interferon gamma signaling 9.26E-12 6.11E-10
Chemokine receptors bind chemokines 1.08E-10 6.17E-09
Signaling by interleukins 6.81E-09 3.41E-07
Insulin-like growth factor-2 mRNA binding proteins (IGF2BPs/IMPs/VICKZs) bind RNA 1.27E-07 0.000005581122619
Antiviral mechanism by IFN-stimulated genes 0.000001933058349 0.00007732233398
CD163 mediating an anti-inflammatory response 0.000007798676169 0.0002807523421
OAS antiviral response 0.00001020870997 0.0003368874291
Peptide ligand-binding receptors 0.00001714057687 0.0005142173062
Interleukin-4 and Interleukin-13 signaling 0.0001014948661 0.002841856252
Cyclin A/B1/B2-associated events during G2/M transition 0.0001887816465 0.00490832281
G0 and early G1 0.0003607121838 0.009017804596
Interleukin-6 signaling 0.0004656678444 0.01071036042
ISG15 antiviral mechanism 0.0008313991988 0.01745938317
Regulation of APC/C activators between G1/S and early anaphase 0.0008313991988 0.01745938317
Polo-like kinase-mediated events 0.001110506513 0.02221013026
APC/C-mediated degradation of cell cycle proteins 0.001308103581 0.02354586446
Regulation of mitotic cell cycle 0.001308103581 0.02354586446
G2/M DNA replication checkpoint 0.001750156332 0.02975265764
Class A/1 (rhodopsin-like receptors) 0.002355063045 0.03537666782
Interleukin-6 family signaling 0.002358444521 0.03537666782
TNFs bind their physiological receptors 0.002358444521 0.03537666782