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. 2021 Aug 13;10:e66417. doi: 10.7554/eLife.66417

Table 5. Downregulated genes and pathways: healthy vs COVID-19 lung (GSE151764).

Genes
CX3CR1 JAML KLRB1 GRAP2 CD226
ARG1 CX3CR1 LY9 MMP9 CD160
MPO HLA-DQB2 CCL17 RORC FOXP3
IL2 TNFRSF9 CCL22 CCR4 CRTAM
BCL2 CXCR5 TCF7 IRS1 CCR6
CA4 CD1C CXCR4 ITK CEACAM8
IGF1R CD69 CD83 KLRG1 PTGS2
Pathways
Name p-value FDR
Chemokine receptors bind chemokines 2.85E-11 4.98E-09
Immune system 1.25E-10 1.09E-08
Interleukin-4 and interleukin-13 signaling 2.82E-09 1.64E-07
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 4.31E-07 0.00001853717999
Peptide ligand-binding receptors 6.71E-07 0.00002348305743
Signaling by Interleukins 0.000001503658493 0.0000436060963
Cytokine signaling in Immune system 0.00002606505855 0.0006516264636
Dectin-1-mediated noncanonical NF-kB signaling 0.00008640543215 0.001814514075
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell 0.0001083388675 0.002058438482
Class A/1 (rhodopsin-like receptors) 0.0001833048828 0.003116183008
Interleukin-10 signaling 0.0002366961934 0.0035504429
RUNX3 regulates immune response and cell migration 0.0005791814113 0.007747184934
Extra-nuclear estrogen signaling 0.0005959373026 0.007747184934
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 0.0006992547523 0.008391057028
CLEC7A (Dectin-1) signaling 0.0008228035145 0.00905083866
Generation of second messenger molecules 0.001171991908 0.01171991908
Innate immune system 0.001676404092 0.01572360367
GPCR ligand binding 0.001747067074 0.01572360367
Adaptive immune system 0.002059835991 0.01853852391
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 0.00467005583 0.03736044664
C-type lectin receptors (CLRs) 0.00545804495 0.0436643596
Transcriptional regulation by RUNX3 0.008124332599 0.05687032819
BMAL1:CLOCK, NPAS2 activates circadian gene expression 0.009518272709 0.06662790896
ESR-mediated signaling 0.01207376237 0.08451633662
Transcriptional regulation by RUNX1 0.01288156371 0.08786708747
TCR signaling 0.01464451458 0.08786708747