Skip to main content
. 2021 Aug 13;10:e66417. doi: 10.7554/eLife.66417

Table 7. Upregulated genes and pathways: uninfected vs infected (48 hpi) lung organoid monolayers.

Genes
IFI35 EPSTI1 AMIGO2 IFITM2
SLC4A11 CMPK2 WARS1 FAAP100
APOL1 OASL IFI27 ISG15
OAS3 IFI44L CD14 SLC35F6
IFIT3 IFI44 SAMD9L
IFIT2 PARP9 SRP9P1
Pathways
Name p-value FDR
Interferon signaling 1.11E-16 4.22E-15
Interferon alpha/beta signaling 1.11E-16 4.22E-15
Cytokine signaling in Immune system 1.15E-10 2.89E-09
Immune system 0.000002540114879 0.00004826218271
OAS antiviral response 0.0004764545663 0.007146818495
Antiviral mechanism by IFN-stimulated genes 0.001033347261 0.01240016713
Interferon gamma signaling 0.001889694619 0.02078664081
Transfer of LPS from LBP carrier to CD14 0.006318772245 0.05686895021
TRIF-mediated programmed cell death 0.02091267586 0.1656073329
MyD88 deficiency (TLR2/4) 0.03733748271 0.1656073329
IRAK2-mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 0.03733748271 0.1656073329
TRAF6-mediated induction of TAK1 complex within TLR4 complex 0.03937173812 0.1656073329
IRAK4 deficiency (TLR2/4) 0.03937173812 0.1656073329
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 0.04140183322 0.1656073329
Caspase activation via death receptors in the presence of ligand 0.04140183322 0.1656073329
IKK complex recruitment mediated by RIP1 0.04948077476 0.1855013265