Table 2.
Age, Months | Carriage Endpoint | Vaccine | Dosing Compared | Bedouin Children | Jewish Children | ||
---|---|---|---|---|---|---|---|
Exposure vs Reference | Eligible Case Population | Match-Eligible Non-case Population | Eligible Case Population | Match-Eligible Non-case Population | |||
n | n | n | n | ||||
≤12 | PCV7 serotypes | PCV7/13 | 1p vs 0p | 62 | 535 | 15 | 83 |
2p vs 0p | 119 | 985 | 30 | 210 | |||
1p vs 2p | 47 | 379 | 14 | 99 | |||
PCV7 | 1p vs 0p | 47 | 375 | 11 | 47 | ||
2p vs 0p | 54 | 409 | 11 | 73 | |||
1p vs 2p | 43 | 192 | 10 | 49 | |||
PCV13 | 1p vs 0p | 44 | 453 | 10 | 68 | ||
2p vs 0p | 54 | 494 | 16 | 97 | |||
1p vs 2p | 40 | 362 | 14 | 99 | |||
PCV13 serotypes | PCV13 | 1p vs 0p | 101 | 637 | 19 | 131 | |
2p vs 0p | 113 | 742 | 28 | 172 | |||
1p vs 2p | 94 | 622 | 23 | 164 | |||
+6PCV13 serotypes | PCV13 | 1p vs 0p | 57 | 552 | 9 | 71 | |
2p vs 0p | 59 | 548 | 12 | 78 | |||
1p vs 2p | 54 | 435 | 9 | 73 | |||
13–25 | PCV7 serotypes | PCV7/13 | 0p+0p vs 2p+1b | 23 | 112 | 17 | 121 |
2p+0b vs 2p+1b | 31 | 213 | 13 | 137 | |||
1p+1b vs 2p+1b | 19 | 112 | 13 | 116 | |||
0p+2b vs 2p+1b | 21 | 115 | 14 | 124 | |||
PCV7 | 0p+0p vs 2p+1b | 10 | 23 | 6 | 12 | ||
2p+0b vs 2p+1b | 9 | 36 | 1 | 6 | |||
1p+1b vs 2p+1b | 5 | 21 | 2 | 7 | |||
0p+2b vs 2p+1b | 8 | 33 | 3 | 16 | |||
PCV13 | 0p+0p vs 2p+1b | 18 | 90 | 15 | 100 | ||
2p+0b vs 2p+1b | 18 | 141 | 11 | 115 | |||
1p+1b vs 2p+1b | 12 | 84 | 10 | 94 | |||
0p+2b vs 2p+1b | 11 | 75 | 10 | 94 | |||
PCV13 serotypes | PCV13 | 0p+0p vs 2p+1b | 31 | 163 | 18 | 114 | |
2p+0b vs 2p+1b | 33 | 218 | 15 | 141 | |||
1p+1b vs 2p+1b | 24 | 147 | 12 | 103 | |||
0p+2b vs 2p+1b | 23 | 143 | 13 | 108 | |||
+6PCV13 serotypes | PCV13 | 0p+0p vs 2p+1b | 13 | 96 | 3 | 14 | |
2p+0b vs 2p+1b | 15 | 120 | 4 | 26 | |||
1p+1b vs 2p+1b | 12 | 89 | 2 | 9 | |||
0p+2b vs 2p+1b | 12 | 87 | 3 | 19 | |||
25–59 | PCV7 serotypes | PCV7/13 | 0p+0p vs 2p+1b | 49 | 272 | 31 | 177 |
2p+0b vs 2p+1b | 18 | 148 | 10 | 86 | |||
1p+1b vs 2p+1b | 17 | 144 | 9 | 79 | |||
0p+2b vs 2p+1b | 21 | 155 | 10 | 81 | |||
PCV7 | 0p+0p vs 2p+1b | 35 | 146 | 23 | 104 | ||
2p+0b vs 2p+1b | 4 | 11 | 1 | 4 | |||
1p+1b vs 2p+1b | 2 | 6 | 1 | 3 | |||
0p+2b vs 2p+1b | 6 | 20 | 2 | 7 | |||
PCV13 | 0p+0p vs 2p+1b | 46 | 246 | 26 | 151 | ||
2p+0b vs 2p+1b | 13 | 111 | 5 | 52 | |||
1p+1b vs 2p+1b | 13 | 109 | 4 | 47 | |||
0p+2b vs 2p+1b | 14 | 110 | 4 | 45 | |||
PCV13 serotypes | PCV13 | 0p+0p vs 2p+1b | 66 | 288 | 52 | 220 | |
2p+0b vs 2p+1b | 16 | 138 | 13 | 100 | |||
1p+1b vs 2p+1b | 16 | 135 | 11 | 95 | |||
0p+2b vs 2p+1b | 17 | 136 | 11 | 91 | |||
+6PCV13 serotypes | PCV13 | 0p+0p vs 2p+1b | 20 | 148 | 26 | 156 | |
2p+0b vs 2p+1b | 3 | 40 | 8 | 71 | |||
1p+1b vs 2p+1b | 3 | 38 | 7 | 67 | |||
0p+2b vs 2p+1b | 3 | 37 | 7 | 64 |
Data indicate numbers of all children available for each comparison (including children eligible for inclusion as cases for whom matched controls, defined irrespective of colonization status, could be identified). As controls could include children carrying vaccine-serotype pneumococci (here listed as “case-eligible” children), the numbers of cases and controls in each analysis iteration do not necessarily correspond to the column entries.
Abbreviations: b, booster; p, primary; +6PCV13, the 6 serotypes contained in PCV13 and not PCV7; PCV7, 7-valent pneumococcal conjugate vaccine; PCV13, 13-valent pneumococcal conjugate vaccine.