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. 2021 Sep 15;2021:5546867. doi: 10.1155/2021/5546867

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Copyright © 2021 Sai Ma et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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NR attenuates the myocardial hypertrophy markers in TAC mice. (a) Narrowed aorta (red arrow) in the TAC group. (b) The HW/BW ratio in the TAC+NR group was significantly reduced compared with the TAC group (5.011 ± 0.109 vs. 5.342 ± 0.323, P < 0.05). (c) NR reduced TAC-induced LW/BW ratio augmentation (7.544 ± 0.332 vs. 8.397 ± 0.320, P < 0.05). (d) NR significantly reduced ANP and BNP in TAC mice (ANP: 1.32 ± 0.08 vs. 1.76 ± 0.06, P < 0.05; BNP: 1.74 ± 0.05 vs. 2.31 ± 0.06, P < 0.05). (e) NR treatment reduced LDH level in hypertrophied mice (2300 ± 221 vs. 2978 ± 332 U/L, P < 0.05). TAC: transverse aortic constriction; HW/BW: heart/body mass ratio; LW/BW: lung/body mass ratio. ^∗P < 0.05 vs. sham group; ^#P < 0.05 vs. TAC group.