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. 2021 Sep 15;2021:5546867. doi: 10.1155/2021/5546867

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Copyright © 2021 Sai Ma et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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NR inhibits NLRP3 inflammasome activation induced by TAC. (a, b) NR significantly reduced the levels of high inflammatory factors caused by myocardial hypertrophy (IL-1β: 233.17 ± 7.12 vs. 267.58 ± 10.23; TNF-α: 366.9 ± 13.40 vs. 472.9 ± 17.30, P < 0.05). (c) Western blot results showed that NR treatment significantly reduced the Caspase-1/Caspase-1 pro and cleaved GSDMD expression in TAC mice (P < 0.05). Furthermore, NR markedly reduced the NLRP3 expression in the TAC+NR group (P < 0.05). There was no significant difference in ASC expression (P > 0.05). NR: nicotinamide riboside. ^∗P < 0.05 vs. sham group; ^#P < 0.05 vs. TAC group.