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. 2020 Nov 7;11(9):2798–2818. doi: 10.1016/j.apsb.2020.11.003

Figure 5.

Figure 5

FR-mediated targeted therapy for IBD. (A) Schematic illustration of fabrication of folat-modified PAMAM dendrimers. (B) Fluorescence image of Cy5.5-labled dendrimer in vivo or ex vivo 12 h after 1 mg/kg Fol-Dend or NT-Dend administration through tail vein injection (n = 4). Colitis mice were induced by drinking 3% DSS water for 6 d λex = 625 nm, λem = 700 nm. (C) The endocytosis of dendrimers by Raw264.7 macrophages after 2 h incubation at 37 °C. λex=670 nm, λem = 700 nm. Reprinted with permission from Ref. 50. Copyright © 2017, American Chemical Society.