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. 2020 Dec 13;11(9):2694–2708. doi: 10.1016/j.apsb.2020.12.005

Table 2.

Comparison between JM#21, WSC02, EPI-X4 and AMD3100.

Compd.	IC₅₀±SEM (μmol/L)
Compd.	12G5^a	X4-HIV-1^b	pERK^c	pAKT^c	Migration^d
EPI-X4	3.24 ± 0.62	5.924 ± 2.49	>100	67.60 ± 30.63	681.63 ± 305.54
WSC02	0.42 ± 0.07	0.25 ± 0.03	15.25 ± 3.97	37.97 ± 26.94	15.83 ± 3.50
JM#21	0.22 ± 0.02	0.007 ± 0.001	1.54 ± 0.51	2.62 ± 1.40	0.48 ± 0.08
AMD3100	0.69 ± 0.05	0.012 ± 0.002	3.28 ± 0.45	35.02 ± 27.22	0.06 ± 0.01

^a

Competition with the CXCR4 specific 12G5 antibody.

^b

Inhibition of CXCR4-tropic HIV-1 on TZM-bl cells.

^c

Inhibition of CXCL12 induced ERK or AKT phosphorylation.

^d

Inhibition of SupT1 migration towards a CXCL12 gradient. IC₅₀ values are represented as mean ± SEM (n = 3).