Skip to main content
. 2021 Mar 18;11(9):2685–2693. doi: 10.1016/j.apsb.2021.03.001

Figure 6.

Figure 6

Analgesic activities of Bu8 in (A) and (B) mice hot plate pain model and (C) acetic acid writhing model. The pain threshold of mice was measured after the administration of (A) MVIIA (0.33, 1, and 3 μg/kg, icv) or (B) Bu8 (0.33, 1, and 3 μg/kg, icv) or saline (icv). (C) 20 min after the single administration of MVIIA (0.33, 1 and 3 μg/kg, icv) or Bu8 (0.33, 1 and 3 μg/kg, icv) or saline (icv), acetic acid was administrated (i.p.) and the writhing number of mice was immediately counted for 5 min. Data were expressed as mean ± SEM (n = 12). ∗P < 0.5 and ∗∗P < 0.01 vs. the MVIIA group at the same dose. All data are presented as mean ± SEM.