Figure 5.
S1-RBD-specific MBCs in SARS-CoV-2-infected individuals make a poor tertiary response
(A–E) Total log10 number of S1-RBD tetramer-binding total MBCs (A), plasmablasts (B), CD21+ cl-MBCs (C), CD21‒ CD27+ pb-MBCs (D), or CD21‒ CD21‒ CD11c+ at-MBCs (E) per million total B cells in the peripheral blood of SARS-CoV-2-naive (black circles) or SARS-CoV-2-infected (red circles) subjects (n = 5–12) at the indicated times after the second vaccination. Box and whisker plots are formatted as in Figure 1C. Values were compared with one-way ANOVA. ∗p < 0.05, ∗∗∗∗p < 0.0001, ns, not significant.