. Author manuscript; available in PMC: 2022 Oct 1.

Published in final edited form as: Ophthalmology. 2021 Mar 27;128(10):1384–1392. doi: 10.1016/j.ophtha.2021.03.030

Table 3.

Associations of systemic conditions with OSDI at baseline, 6 months, and 12 months combined.

	OSDI
	No	Yes
	Mean (SD)	Mean (SD)	p^*
Sjögren’s syndrome	34.3 (18.4)	38.1 (18.0)	0.16
Rosacea (facial)	34.7 (18.4)	36.8 (18.6)	0.15
Rheumatoid arthritis^†	34.0 (18.3)	37.5 (18.6)	0.15
Daily smoking history	34.3 (18.6)	37.0 (18.2)	0.03
Peripheral artery disease	34.9 (18.5)	38.1 (17.8)	0.10
Thyroid dysfunction	35.4 (18.6)	34.4 (18.4)	0.52
Osteoarthritis	35.0 (18.9)	34.7 (16.9)	0.92
Diabetes	35.0 (18.2)	36.3 (19.9)	0.31
Irritable bowel syndrome	34.8 (18.4)	38.2 (19.4)	0.26
Hypercholesterolemia	35.9 (18.7)	34.1 (17.9)	0.32
Hypertension	35.6 (18.7)	34.1 (18.0)	0.65
Hypertriglyceridemia	35.2 (18.6)	34.4 (15.8)	0.84

P-values for the statistical significance of association between a systemic condition and OSDI were calculated from generalized linear regression models adjusted by age, sex, race, and visit. Generalized estimating equations (GEE) were used to account for inter-visit and inter-eye correlations within the same subject.

^†

Excluding patients meeting 2012 ACR criteria for Sjögren’s syndrome.