TABLE 1.
B‐Cell Subset | Markers | Refs. |
---|---|---|
B1 B cells | ||
B1a | CD19+ CD5+ CD11b+/− B220lo IgMhi IgDlo CD23− CD43+ | ( 35 ) |
B1b | CD19+ CD5− B220lo IgMhi IgDlo CD23− CD43+ | ( 35 ) |
B2 B cells | ||
Follicular | CD19+ B220+ IgMlow IgDhi CD21med CD1dlow CD23+ | ( 35 ) |
Marginal zone | CD19+ B220+ IgMhi IgDlow CD1dhi CD21hi CD23‐ | ( 35 ) |
Memory | CD19+ B220low/+ CD21+ CD95+ CD40+ CD273+ CD73+ CD80+ | ( 83 ) |
Plasma cells | CD138+ CD93+ CXCR4+ CD44+ VLA‐4+ BCMA+ IL6‐R+ | ( 84 ) |
Regulatory | CD19+ PD‐L1+/− Tim‐1+/− FasL+/− LAG‐3+/− | ( 38 ) |
Abbreviations: BCMA, B‐cell maturation antigen; FasL, Fas ligand; LAG‐3, lymphocyte activation gene‐3; Tim‐1, T‐cell immunoglobulin and mucin domain 1; VLA‐4, very late antigen‐4.