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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Curr Opin Microbiol. 2021 Jul 1;63:59–65. doi: 10.1016/j.mib.2021.06.003

Figure 2:

Figure 2:

Gut-brain axis interactions observed in Citrobacter rodentium-infected mice. During infection, CR can sense different host neurochemical signals (epinephrine [Epi]/norepinephrine [NE], serotonin and 2-arachidonoylglycerol [2-AG]) to regulate virulence gene expression and colonization of the gut. CR infection alters microbial composition and increases gut inflammation inducing gut dysbiosis. Alterations in inflammation and microbial composition have been related to changes in behavioral responses and brain pathologies. At the same time, stressful situations and brain disorders have been related to changes in gut physiology and microbiota composition which, in turn, affect CR colonization and disease.