Table 2.

Function of select significant HSPC microRNA (miR).

miR	Function	Reference
miR-145	differentially regulates hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling	(34)
miR-494	associated with expansion of myeloid derived stem cells through activation of the NFkB	(35)
miR-125a	expression is associated with an expansion of HSPCs	(36)
miR-125b	overexpression in hematopoietic stem cells promotes self-renewal, differentiation and expansion	(22)
miR-132/124	important for cycling, function, and survival	(55)
miR 196b	miR-21/miR-196b work inhibit myelopoiesis and completely block G-CSF–induced granulopoiesis	(56)
miR-21	elevated levels in myeloid cells enhance proliferation and block myeloid differentiation; expression implicated in increased myeloid-derived suppressor cells and promote immunosuppression in late sepsis	(57)
miR-17–5p	highly expressed in HSPCs and markedly downregulated during monocytic differentiation and maturation	(33)
miR-223–5p	myeloid-specific miR-223 negatively regulates progenitor proliferation and granulocyte differentiation and activation.	(32)