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. 2021 Aug 10;74(4):2201–2215. doi: 10.1002/hep.31919

FIG. 4.

FIG. 4

Treatments of HBL PDXs by Ola inhibit tumor growth of engrafted HBL. (A) Examination of three PDXs by SEC shows that PDXs preserve the ph‐S6‐p53/PARP1/Ku70 complexes. PDXs 17 and 18 are from the Cincinnati Children’s Hospital Medical Center and present examination of the first generation of PDXs. PDX 3(2) is from the regenerated set of PDXs.( 21 ) Nuclear proteins were fractionated on SEC600 column, and levels of proteins in each fraction of SEC were examined by WB. Co‐IP shows the complexes. (B) Tumor volume of the control and Ola‐treated PDXs at different time points after initiation. Fifteen control and 15 Ola‐treated PDXs from 5 patients were used. (C) A summary of tumor volume at day 17. (D) H&E and ki67 staining of the HBL in control and Ola‐treated PDXs. (E) Quantitation of ki67 staining. Abbreviation: Veh, vehicle.