FIG. 5.

Treatments with Ola reduce the ph‐S6‐p53/PARP1 pathway in engrafted PDXs. (A) Ola reduces ph‐S6‐p53/PARP1 complexes in tumor sections of PDXs. Upper part shows the WB of six control PDXs and six Ola‐treated PDXs. Bottom part shows co‐IP studies of the same PDXs. (B) Bar graphs show levels of proteins from (A) as ratios to β‐actin or IgGs in co‐IP. (C) ALCD‐dependent genes are down‐regulated by Ola. (D) Levels of the proteins in (B) were calculated as ratios to β‐actin. (E) WB showing that levels of cell cycle proteins are reduced by Ola treatments. (F) Bar graphs showing levels of cell cycle proteins as ratios to β‐actin.