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. 2021 Sep 24;11:19013. doi: 10.1038/s41598-021-97620-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Additional comparison with degenerated samples for the proteins significantly upregulated in anabolic pathways. (A) Includes the proteins that were absent in healthy adult NP’s, and shows differences in protein expression between fetus and degenerated discs. (B) Includes the proteins that were expressed in a significantly lower amount in healthy adult NP’s compared to fetus and shows the differences in protein expression between healthy adult and degenerated discs. The Y axis displays median normalized PSM’s per group, X axis shows protein gene symbols, error bars are Interquartile ranges and * indicates statistical significance. The attached table contains the median (number of samples) for each group, and provides the according Mann Whitney U p values if statistics could be performed (n ≥ 4). ‘/’ indicates that 3 or less samples were present in one of the groups and no statistical test could be performed.