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. 2021 Sep 24;11:19022. doi: 10.1038/s41598-021-98218-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Model summarizing the relationship between PIGN expression aberration, SAC regulation, and leukemia progression. PIGN depletion results in SAC dysregulation and ultimately results in segregation errors and aneuploidy which contribute to leukemia progression. PIGN plays a vital role in the regulation of mitotic integrity to maintain chromosomal stability.