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. 2021 Sep 24;11:19011. doi: 10.1038/s41598-021-97866-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo characterisation of emm type 32.2 (isolate 112,327) and emm type 1.0 (isolate 101,910) in a model of invasive GAS infection. (A) Kaplan Meier plots representing percentage survival of CD1 mice (n = 10 per group) following 10⁸ and 10⁷ CFU intravenous infection with emm type 1.0 (isolate 101,910) and emm type 32.2 (isolate 112,327). (B) The bacterial CFU in blood for each isolate and infectious dose over time. (C) The bacterial CFU in knee joints of CD1 mice (n = 10, knee joints n = 20) following intravenous infection with 10⁷ CFU (50 μl) of emm type 1.0 (isolate 101,910). **p value < 0.01 when analysed using a one-way ANOVA followed by a Kruskall-Wallis multiple comparisons test.