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. 2021 Sep 24;11:19011. doi: 10.1038/s41598-021-97866-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of concentration and activity of secreted SLO on virulence in vivo. (A) Concentration of streptolysin (ng/ml) and (B) haemolytic activity in infection doses of emm type 1.0 (isolate 101,910) and emm type 32.2 (isolate 112,327), when prepared in 1 ml of PBS, incubated at room temperature for 30 min. (C) Kaplan Meier survival plots representing survival of CD1 mice (n = 10 per group) when intravenously infected (10⁸ CFU) with isolates 101,910 and 112,327, and 112,327 bacteria re-suspended in supernatant from 101,910 challenge dose (112,327 S) or 101,910 bacteria re-suspended in supernatant from 112,327 challenge dose (101,910 S). (D) Bacterial burden in blood 24 h after infection with isolates 101,910 and 112,327 and swapped supernatant isolates as above. **p value < 0.01, ***p < 0.005 and ****p value < 0.001 when analysed using a one-way ANOVA followed by a Kruskall-Wallis multiple comparisons test.