Table 2.
The factors related to the levels of ADCC fold induction and neutralization ED50 among the COVID-19 patients by generalized estimation equation
| Factors | ADCC fold induction | Neutralization ED50a | ||
|---|---|---|---|---|
| β (95% CI) | P | β (95% CI) | P | |
| Age, years | ||||
| <45 | 1.00 (reference) | 1.00 (reference) | ||
| 45–60 | 0.042 (−0.112, 0.197) | 0.591 | 0.060 (−0.096, 0.216) | 0.452 |
| ≥60 | −0.053 (−0.208, 0.101) | 0.499 | 0.119 (−0.045, 0.282) | 0.155 |
| Sex | ||||
| Male | 1.00 (reference) | 1.00 (reference) | ||
| Female | −0.079 (−0.218, 0.06) | 0.267 | −0.016 (−0.154, 0.123) | 0.823 |
| Clinical type | ||||
| Asymptomatic | 1.00 (reference) | 1.00 (reference) | ||
| Mild | 0.153 (−0.124, 0.43) | 0.278 | −0.244 (−0.508, 0.020) | 0.070 |
| Moderate | 0.265 (0.001, 0.529) | 0.049 | 0.094 (−0.159, 0.347) | 0.468 |
| Severe | 0.549 (0.279, 0.818) | <0.001 | 0.225 (−0.036, 0.486) | 0.091 |
| Day from symptom onset to sampling | ||||
| 1−10 days | 1.00 (reference) | 1.00 (reference) | ||
| 11–20 days | 0.459 (0.299, 0.619) | <0.001 | 0.142 (−0.006, 0.290) | 0.060 |
| 21–30 days | 0.226 (0.021, 0.432) | 0.031 | 0.393 (0.253, 0.532) | <0.001 |
| 1–6 months | −0.292 (−0.445, −0.138) | <0.001 | 0.234 (0.081, 0.388) | 0.003 |
| 1 year | −0.047 (−0.259, 0.165) | 0.665 | −0.035 (−0.254, 0.185) | 0.756 |
ADCC antibody-dependent cell-mediated cytotoxicity, CI confidence interval, COVID-19 coronavirus disease 2019
aThe value of neutralization ED50 was log10-transformed