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. 2021 Sep 24;6:346. doi: 10.1038/s41392-021-00759-1

Table 2.

The factors related to the levels of ADCC fold induction and neutralization ED50 among the COVID-19 patients by generalized estimation equation

Factors ADCC fold induction Neutralization ED50a
β (95% CI) P β (95% CI) P
Age, years
<45 1.00 (reference) 1.00 (reference)
45–60 0.042 (−0.112, 0.197) 0.591 0.060 (−0.096, 0.216) 0.452
≥60 −0.053 (−0.208, 0.101) 0.499 0.119 (−0.045, 0.282) 0.155
Sex
Male 1.00 (reference) 1.00 (reference)
Female −0.079 (−0.218, 0.06) 0.267 −0.016 (−0.154, 0.123) 0.823
Clinical type
Asymptomatic 1.00 (reference) 1.00 (reference)
Mild 0.153 (−0.124, 0.43) 0.278 −0.244 (−0.508, 0.020) 0.070
Moderate 0.265 (0.001, 0.529) 0.049 0.094 (−0.159, 0.347) 0.468
Severe 0.549 (0.279, 0.818) <0.001 0.225 (−0.036, 0.486) 0.091
Day from symptom onset to sampling
1−10 days 1.00 (reference) 1.00 (reference)
11–20 days 0.459 (0.299, 0.619) <0.001 0.142 (−0.006, 0.290) 0.060
21–30 days 0.226 (0.021, 0.432) 0.031 0.393 (0.253, 0.532) <0.001
1–6 months −0.292 (−0.445, −0.138) <0.001 0.234 (0.081, 0.388) 0.003
1 year −0.047 (−0.259, 0.165) 0.665 −0.035 (−0.254, 0.185) 0.756

ADCC antibody-dependent cell-mediated cytotoxicity, CI confidence interval, COVID-19 coronavirus disease 2019

aThe value of neutralization ED50 was log10-transformed